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Pediatric Endocrinology

The Endocrine System

The endocrine system is an intricate collection of hormone-producing glands scattered throughout the body. As an interrelated group, these glands influence almost every cell, organ and function of our bodies, helping to control mood, metabolism, growth, tissue function and sexual development.

Some glands have both endocrine and non-endocrine regions. For example, the pancreas secretes digestive enzymes as well as hormones. Some organs (such as the stomach, intestines and heart) produce hormones even though their primary function is not hormone secretion.

Major Glands of the Endocrine System and What They Do

Adrenal (suprarenal) glands

Location The top of each kidney.
Hormones produced Catecholamines (adrenaline or epinephrine); mineralocorticoids (like aldosterone); glucocorticoids (like cortisol); steroid hormones (like androgen).
Function Help control metabolism, kidney function, blood pressure, cardiovascular function, the body’s response to stress, the immune system, and sexual development and function. Help balance the effects of insulin in breaking down sugar for energy.

Gonads

Location Female ovaries – on each side of the uterus
Male testes – in the scrotum
Hormones produced Ovaries – Estrogen and progesterone

Testes – Androgens (testosterone)

Function Regulate puberty and fertility.

Ovaries – Induce female sexual characteristics such as breast growth, the accumulation of body fat around the hips and thighs, and the growth spurt that occurs during puberty. Both estrogen and progesterone are also involved in regulating the menstrual cycle and pregnancy.

Testes – Induce male sexual characteristics such as maturation of the penis, deepening of the voice, development of muscles, increase in facial and body hair and the growth spurt that occurs during puberty. They also regulate sex drive and are involved in production of sperm cells.

Hypothalamus

Location Lower central part of the brain.
Hormones produced Produces releasing hormones for the pituitary gland.
Function

Stimulates or suppresses the release of hormones in the pituitary gland to control water balance, sleep, temperature, appetite and blood pressure. Serves as the primary link between the endocrine and nervous systems.

Pancreas

Location Behind the stomach.
Hormones produced Insulin, gastrin, glucagon, somatostatin.
Function Regulates the level of sugar in the bloodstream and keeps the muscles supplied with glucose.

Parathyroid glands

Location Above and below the thyroid.
Hormones produced Parathyroid hormone.
Function Regulate calcium and phosphorous concentrations in the bloodstream.

Pineal gland

Location Middle of the brain.
Hormones produced Melatonin.
Function Helps regulate the wake-sleep cycle.

Pituitary gland

Location Base of the brain under the hypothalamus.
Hormones produced Adrenocotropic hormone (ACTH), antidiuretic hormone, corticotropin,
luteinizing hormone (LH), follicle stimulating hormone (FSH), human growth hormone (hGH), oxytocin, prolactin, thyrotropin.
Function

Controls the activity of many other endocrine glands (thyroid, ovaries, adrenal). Helps with functions such as the growth of long bones, muscles and viscera; body water balance; utilization of nutrients and minerals; sensitivity to pain. In females, it helps to stimulates egg production, prepares the uterus for pregnancy, triggers contractions that occur during labor, activates milk production for breastfeeding.
In men, it helps to stimulates sperm production.

Thyroid gland

Location Front portion of the lower neck.
Hormones produced Thyroxine, triiodothyronine, calcitonin
Function Helps to regulate metabolism (including weight control and energy levels), the body's calcium balance, muscle strength, emotions, the ability to tolerat heat or cold and the development of the brain and nervous system in children.

 

Thymus gland

Location In the chest just under the breastbone.
Hormones produced Thymosin
Function Development of the body’s immune system.

 

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