Flaum Eye Institute

Krystel Huxlin, Ph.D.

Associate Professor
Department of Ophthalmology
Neurobiology and Anatomy
Center for Visual Science
Brain & Cognitive Science

Publications

Huxlin Lab Links Home Research Team Publications, Presentations & Patents Honors & Awards Teaching

Peer-reviewed journal articles and book chapters
1.  Nagy, L.J., Ding, L., Xu, L., Knox, W.H. and Huxlin, K.R. (2009) Potentiation of femtosecond laser intratissue refractive index shaping (IRIS) in the living cornea with sodium fluorescein. (In review at IOVS - Ms. No. IOVS-09-3901).
2.      Hindman, H.B., Swanton, J., Phipps, R.P. and Huxlin, K.R. (2009) Differences in the TGFbeta-induced pro-fibrotic response of anterior and posterior corneal keratocytes in vitro (In review at IOVS - Ms. No. IOVS-09-3823).
3.  Martin, T. and Huxlin, K.R. (2009) Spontaneous and Training-Induced Visual Learning in Cortical Blindness: Characteristics and Neural Substrates. Topics in Cognitive Science (in press - Ms. No. S-09-81).
4.   Ferguson H.E., Kulkarni, A., Lehmann G.M., Garcia-Bates T.M., Thatcher T.H., Huxlin K.R., Phipps R.P. and Sime, P.J. (2009) Electrophilic PPAR_ ligands have potent anti-fibrotic effects in human lung fibroblasts. American Journal of Respiratory Cell and Molecular Biology (in press - Ms. No. Red-2009-0006C.R1).
5.       Bühren, J., Yoon, G., MacRae, S. and Huxlin, K.R. (2009) Contribution of optical zone decentration and pupil dilation on the change of optical quality after photorefractive keratectomy (PRK) in a cat model. Journal of Refractive Surgery (in press - Ms. No. JRS-2008-250 Version 1)
6.      Huxlin K.R., Martin T., Riley M., Kelly K., Friedman D.I., Burgin W.S. and Hayhoe M. (2009) Perceptual re-learning of complex visual motion after V1 damage in humans. Journal of Neuroscience 29: 3981 - 3991.
7.       Bühren, J., Nagy, L.J., Swanton, J.N., Kenner, S., Yoon, G., MacRae, S.M., Phipps, R., Huxlin, K.R. (2009) Optical effects of anti-TGF¾ treatment after photorefractive keratectomy in a cat model. IOVS 50: 634 - 643.
8.       Ding, L., Bühren, J., Nagy, L.J., Knox, W. and Huxlin, K.R. (2008) Intra-stromal Refractive Index Shaping (IRIS) of the cornea and lens using a low-pulse-energy femtosecond laser oscillator. IOVS 49: 5332 - 5339.
9.  Huxlin, K.R. (2008) Perceptual plasticity in damaged adult visual systems. Vision Research Reviews - Vision Research 48: 2154 - 2166.
10.     Huxlin, K.R. Williams, J.M. and Price, T. (2008) A neurochemical signature of visual recovery after extrastriate cortical damage in the adult cat. Journal of Comparative Neurology 508: 45 - 61.
11.    Martin T., Riley M.E., Kelly K., Hayhoe M. and Huxlin K.R. (2007) Visually-guided behavior of homonymous hemianopes in a naturalistic task. Vision Research 47: 3434 - 3446.
12. Bühren, J., Yoon, G., Kenner, S., MacRae, S. and Huxlin, K.R. (2007) The effect of optical zone decentration on lower- and higher-order aberrations after photorefractive keratectomy (PRK) in a cat model. Investigative Ophthalmology and Vision Science 48: 5806 - 5814.
13.  Nagy L. J., MacRae S., Yoon G., Cox I. and Huxlin K.R. (2007) Photorefractive keratectomy in the cat eye: biological and optical outcomes. Journal of Cataract and Refractive Surgery 33: 1051 - 1064.
14.       Huxlin, K.R. (2007) "Human Vision". In The Focal Encyclopedia of Photography. M. Peres, G. Romer, D. Malin, M. Osterman, N. Stuart, S. Williams, F. Frey and T. Lopez (Eds). Elsevier Inc.
15.   Huxlin, K.R. (2006) "Neurochemical changes underlying motion perception plasticity after visual cortex lesions". In Reprogramming The Cerebral Cortex: Plasticity Following Central And Peripheral Lesions. S.G. Lomber and J. J. Eggermont (Eds). Oxford University Press.
16.  Huxlin K.R., Yoon G., Nagy L., Porter J. and Williams D.R. (2004) Monochromatic ocular wavefront aberrations in the awake-behaving cat. Vision Research 44: 2159 - 2169.
17.     Huxlin K.R. and Pasternak T. (2004) Training-induced recovery of motion perception after extrastriate cortical damage in the adult cat. Cerebral Cortex 14: 81 - 90.
18. Huxlin K.R. and Pasternak T. (2001) Long-term neurochemical changes after visual cortical lesions in the adult cat.  Journal of Comparative Neurology 429: 221 - 241.
19.        Huxlin K.R., Saunders R., Marchionini D., Pham H-A. and Merigan W.H. (2000) Perceptual deficits after lesions of inferotemporal cortex in macaques.  Cerebral Cortex 10: 671 - 683.
20.  Huxlin K.R. and Merigan W.H. (1998) Deficits in complex visual perception following unilateral temporal lobectomy.  Journal of Cognitive Neuroscience 10: 395 - 407.
21. Wang C., Dreher B., Huxlin K.R. and Burke W. (1997) Excitatory convergence of Y and non-Y information channels on single neurons in the PMLS area, a motion area of cat visual cortex.  European Journal of Neuroscience 9: 921 - 933.
22.       Huxlin K.R. and Goodchild A.K. (1997) Retinal ganglion cells in the albino rat: revised morphological classification.  Journal of Comparative Neurology 385: 309 - 323.
23.      Bennett M.R. and Huxlin K.R. (1996) Neuronal cell death in the mammalian nervous system: the calmortin hypothesis [review].  General Pharmacology 27: 407 - 419. 
24.    Huxlin K.R. and Bennett M.R. (1995) NADPH-diaphorase expression in the mammalian retina after axotomy - a supportive role for nitric oxide?  European Journal of Neuroscience 7: 2226 - 2239.
25.        Huxlin K.R. (1995) NADPH-diaphorase expression in neurons and glia of the normal adult rat retina.  Brain Research 692: 195 - 206.
26.   Huxlin K.R., Dreher Z., Schulz M. and Dreher B. (1995) Glial reactivity in the retina of adult rats.  Glia 15: 105 - 118.
27.    Huxlin K.R., Dreher B., Schulz M., Sefton A. and Bennett M.R. (1995) Effect of collicular proteoglycan on the survival of adult rat retinal ganglion cells following axotomy.  European Journal of Neuroscience 7: 96 - 107.
28. Huxlin K.R., Carr R., Schulz M., Sefton A. and Bennett M.R. (1995) Trophic effect of collicular proteoglycan on neonatal rat retinal ganglion cells in situ.  Developmental Brain Research 84: 77 - 88.
29.      Huxlin K.R., Sefton A.J., Schulz M. and Bennett M.R. (1993) Effect of proteoglycan purified from rat superior colliculus on the survival of murine retinal ganglion cells.  Developmental Brain Research 74: 207 - 217.
30.      Huxlin K.R., Sefton A. and Furby J.H. (1992) The origin and development of retinal astrocytes in the mouse.  Journal of Neurocytology 21: 530 - 544.
31. Huxlin K.R., Sefton A. and Furby J.H. (1992) Explantation of fetal murine retinae to the chorioallantoic membrane of the chicken embryo.  Journal of Neuroscience Methods 41: 43 - 64.
32.     Huxlin K.R., Tuch B.E., Sefton A.J. and Dixon G. (1990) Grafting of fetal pancreata into neonatal rat brain.  Transplantation 49: 857 - 861.
33. Huxlin K.R., Tuch B.E., Sefton A.J. and Dixon G. (1989) Iso-, allo- and xenografting of fetal pancreata into neonatal rat brain.  Transplantation Proceedings 21: 3807 - 3808.

In preparation
Riley M.E., Kelly K., Martin T., Hayhoe M. and Huxlin K.R. Implications of cortical blindness for visual function in a dynamic visual environment. (To be submitted to Journal of Vision)
Martin T., Riley M. and Huxlin K.R.. Visual motion retraining can restore BOLD responses in chronic hemianopia: A case report. (To be submitted to NeuroImage)
Nagy L. J., Kraftschick B., Ciufo D., Yoon G., MacRae S., Bühren J. and Huxlin K.R. The biological contribution to optical aberrations induced by phototherapeutic keratectomy. (To be submitted to JCRS).

Huxlin, K.R., Nagy, L., Wyble, M., Beha, M., Wang, J., Cox, I. and MacRae, S. Short-term optical and biomechanical reaction of experimentally thinned corneas after laser refractive surgery.

Book Reviews
Huxlin, K.R. (1998) Book Review on: "Cerebral Cortex, Vol 12, Extrastriate Cortex in Primates", edited by Rockland, Kaas and Peters. Trends in Neurosciences vol. 21, pp. 499.

RECENT CONFERENCE PRESENTATIONS
Martin, T., Das, A. and Huxlin, K.R. (2009) Visual motion retraining of a cortically-blind field increases BOLD responses in peri-lesional cortex and MT+ - a case study. VSS meeting.
Das, A., Martin, T. and Huxlin, K.R. (2009) Compensatory changes in activity in effector circuitries during visually guided behavior following V1 damage in humans. VSS meeting.
Kuriyan, A.E., Lehmann, G.M., Feldon, S.E., Sime, P., Huxlin, K.R., Phipps, R.P. (2009) Synthetic triterpenoids inhibit human corneal myofibroblast differentiation in vitro. ARVO meeting.
Hindman, H.B., Swanton, J.N. , Phipps, R.P. , Huxlin, K.R.  (2009) Anterior and Posterior Cultured Cat Keratocytes Respond Differently to TGF-b Stimulation. ARVO Meeting.
Nagy, L.J., Ding, L., Xu, L., Bubel, T., Swanton, J., Knox, W.H. and Huxlin, K.R. (2009) Potentiating femtosecond intra-tissue refractive index shaping (IRIS) in the living cornea with sodium fluorescein doping. ARVO meeting.
Ding L., Nagy L., Xu L., Chang J., Swanton J., Knox W.H. and Huxlin K.R. (2009) Enhancement of Intra-tissue Refractive Index Shaping (IRIS) of the cornea by Two-Photon Absorption. CLEO/IQEC Meeting.
Bühren, J., Nagy, L. Yoon, G., MacRae, S. and Huxlin, K.R. (2009) The effect of the asphericity of myopic laser ablation profiles on the induction of wavefront aberrations. ARVO meeting.
Martin, T., Riley, M.E. and Huxlin, K.R. (2008) Contributions of prefrontal cortex to response latency for direction discrimination of visual motion: evidence from fMRI. Society for Neuroscience Meeting.
Huxlin, K.R., Ding., L. and Knox, W. (2008) Using a femtosecond laser to alter the refractive index of the cornea and lens. ARVO Meeting.
Bühren J., Yoon G., DiMagistris, M., MacRae S. and Huxlin K.R. (2008) Biological correlates of higher-order aberrations (HOAs) after photorefractive keratectomy (PRK) in a cat model. ARVO Meeting.
Huxlin, K.R., Riley, M., Martin, T., Kelly, K. and Hayhoe M. (2007) Complex visual learning in the absence of V1. Vision Down Under meeting, Cairns, Australia.
Huxlin, K.R. (2007) Improving global motion perception in the blind field of adult humans with V1 damage. Vision Sciences Society meeting, Symposium on "Visual Plasticity in Abnormal and Damaged Adult Brains".
Ding, L., Huxlin, K.R. and Knox, W.H. (2007) Intrastromal refractive index change induced in cat corneas by femtosecond laser micromachining. OSA Meeting.
Martin T., Kelly K., Riley M.E., Hayhoe M. and Huxlin K.R. (2007) Hemianopic gaze dynamics in a naturalistic task. Vision Science Society Meeting
Riley M.E., Kelly K., Martin T., Hayhoe M. and Huxlin K.R. (2007) Homonymous hemianopia alters distribution of visual fixations in 3-dimensional virtual environments. Vision Science Society Meeting
Bühren J., Yoon G., Kenner S., Artrip S., MacRae S. and Huxlin K.R. (2007) The effect of pupil decentration on lower- and higher-order aberrations after myopic photorefractive keratectomy (PRK) in a cat model. ARVO meeting.
Huxlin K.R., Bühren J., Kenner S., Nagy L., Wyble M., Beha M. and MacRae S. (2007) Blocking myofibroblast differentiation decreases higher order optical aberrations after PRK in a cat model. ARVO meeting.
Bühren J., Yoon G., Kenner S., Artrip S., MacRae S., Huxlin K.R. (2007) The effect of pupil decentration on lower- and higher-order aberrations after myopic photorefractive keratectomy (PRK) in a cat model. Wavefront Congress.
Kelly K., Sullivan B., Hayhoe M. and Huxlin K.R. (2006) Training-induced improvements in motion sensitivity after V1 damage in humans. 25rd CVS Symposium "Statistical Learning and Brain Plasticity", University of Rochester.
Riley M., Martin T., Kelly K., Hayhoe M. and Huxlin K.R. (2006) Homonymous hemianopia alters the distribution of fixations in a 3D virtual environment. 25rd CVS Symposium "Statistical Learning and Brain Plasticity", University of Rochester.
Kelly K., Sullivan B., Hayhoe M. and Huxlin K.R. (2006) Training-induced improvements in motion sensitivity after V1 damage in humans. 31st Annual Rochester Ophthalmology Conference, University of Rochester.
Huxlin K.R., Nagy L., Wyble M., Beha M., Wang J., Cox I. and MacRae S. (2006) Short-term optical and biomechanical reaction of experimentally thinned corneas after laser refractive surgery. ARVO meeting.
Wyble, M., Wang, J., MacRae, S., Fischer, W. and Huxlin, K.R. (2006) Quantification of stromal reflectivity changes induced by photorefractive keratectomy in the cat. ARVO meeting.
Huxlin, K.R. (2006) Plasticity of visual perception after permanent damage to the adult visual cortex. Invited lecture in the Visual Field Restoration Therapy Symposium, NANOS Annual Meeting, Tuscon, AZ.
Merigan, W.H., Gee, B. and Huxlin, K.R. (2005) Projections from ON and OFF P retinal ganglion cells to macaque LGN are not segregated. ARVO meeting.
Nagy, L.J., Yoon, G., MacRae, S., Cox, I., Beha, M. and Huxlin, K.R. (2005) The contribution of corneal biomechanics to optical aberrations after PTK. ARVO meeting.
Beha, M., Nagy, L., Wang, J., Cox, I., MacRae, S. and Huxlin, K.R. (2005) Biomechanical substrates of hyperopic shifts in the defocus term after PTK. ARVO meeting.
Huxlin, K.R., Williams, J.M., Sullivan, B. and Hayhoe, M. (2005) Training-induced improvements of visual motion perception after V1 cortical damage in humans. Vision Sciences Society Meeting.
Huxlin, K.R., Williams, J.M. and Hayhoe, M. (2005) Restoring visual motion perception in brain-damaged humans. Invited Lecture at the Vision 2005 symposium - "Restoration of Vision After Visual System Damage", London, UK.
Huxlin, K.R. (2004) Experience-dependent visual recovery after cortical lesions in adulthood. Invited lecture at the Society for Neuroscience Meeting Minisymposium - "Learning and Neural Plasticity in the Adult Visual System".
Williams, J.M. and Huxlin, K.R. (2004) Training-induced visual recovery after extrastriate lesions is associated with increased GAP43 gene expression in low-level visual cortical areas. Society for Neuroscience Meeting.
Williams, J.M., Hayhoe, M. and Huxlin, K.R. (2004) Training-induced perceptual recovery after visual cortical stroke. OSA Fall Vision Meeting
Huxlin, K.R. (2004) Adult plasticity in the human visual cortex. 49th Annual Rochester Ophthalmology Conference.
Kelts, E.A., Williams, J.M., Feldman, B., Hayhoe, M. and Huxlin, K.R. (2004) Training-induced perceptual recovery after visual cortical stroke. 30th Annual NANOS Meeting, Orlando, FL.
Nagy, L.J., MacRae, S.M., Yoon, G., Cox, I. and Huxlin, K.R. (2004) Ocular wavefront aberrations after laser refractive surgery - a comparison of human and cat eyes. ARVO Meeting.
Williams, J.M. Price, T.M., Funderburk, S. and Huxlin, K.R. (2003) Training-induced alterations in AMPA receptor subunit composition after cortical lesions in adult cats. Society for Neuroscience Meeting.
Huxlin, K.R., Yoon, G., Nagy, L., Brandon, E., Porter, J., Cox, I., MacRae, S. and Williams, D.R. (2003) Ocular wave-front aberrations in awake cats. ARVO Meeting.
K.R. Huxlin and T. Pasternak (2002) Temporal characteristics and stimulus specificity of visual recovery after LS cortical lesions in the adult cat. Society for Neuroscience Meeting.
K.R. Huxlin, G. Yoon, J. Porter, L. Nagy, S. MacRae, I. Cox and D. Williams (2002) Wavefront sensing in an awake, behaving cat model for refractive surgical applications. 23rd CVS Symposium "Engineering the Eye", University of Rochester.
T.A. Price and K.R. Huxlin (2001) Differential effect of adult cortical lesions on Glu receptor expression in projection cells and interneurons of the afferent circuitry. Society for Neuroscience Meeting.
K.R. Huxlin, T. Price and T. Pasternak (2000) Cellular changes associated with visual recovery after cortical lesions in adult cats. Society for Neuroscience Meeting.
N. McFarland, K. Huxlin and S.N Haber (2000) Differential distribution of GAP-43 message in infra- and supragranular layers of the orbital and medial prefrontal cortex. Society for Neuroscience Meeting.
PATENTS
"Systems and methods for improving visual discrimination". Filed with US patent Office January 2006. by Knobbe Martens Olson & Bear LLP, reference #UNIRO.021A. This application claims the benefit of U.S. Provisional Patent Application No. 60/641,589, filed on January 6, 2005, U.S. Provisional Patent Application No. 60/647,619, filed on January 26, 2005, and U.S. Provisional Patent Application No. 60/ 665,909, filed March 28, 2005. Awarded 2009.
"Femtosecond micromachining of refractive index modifications in ocular tissues with low scattering loss". Li Ding, Krystel R. Huxlin, and Wayne H. Knox. UR disclosure 2-11150-07042, Provisional Patent Application No. 60/929,397 filed June 26, 2007.
"Femtosecond Micromachining of Corneal and Lens Tissues with Enhancement of Nonlinear Absorption", Wayne H. Knox, Krystel R. Huxlin and Li Ding. UR Disclosure filed Feb. 27, 2008.

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